Digestive issues are common in children with autism. Experts recommend testing their methyltetrahydrofolate (related to folic acid), which is essential for maintaining good metabolic health.
Certain digestive difficulties are common in children with autism, including constipation, diarrhea, and even itching surrounding the anus.
If any of these symptoms occur, It is recommended to check the patient’s methyltetrahydrofolate. This active substance is related to folic acid—also known as vitamin B9—which is crucial to maintaining a healthy metabolism and building cells.

Children on the autism spectrum, in particular, need to maintain normal methyltetrahydrofolate levels. This helps them ensure ongoing healthy methylation processes.
It also serves as a must for both the synthesis and the breakdown of norepinephrine, dopamine, and serotonin—all critical neurotransmitters.
How to Identify Folic Acid Deficiencies in Children with Autism
There are a number of reasons why healthy folic acid levels are so important in children. These include the following:
- Folic acid facilitates a healthy digestive system, helping to minimize the risk of constipation and diarrhea.
- Folic acid strengthens the brain’s sleep cycles, promoting consistent, effective rest as a result.
- Folic acid plays a critical role in methylation, as low folic acid levels can boost the presence of toxins in the body.
- Folic acid can reduce one’s risk of periodic infection, all while helping to produce white blood cells.
Folic acid is available in both synthetic and natural derivative form. The former (Folacin) is found in dietary supplements, while the latter (Folate) is found in specific foods and supplements.
Common Causes of Folic Acid Deficiency in Children with Autism
A number of factors cause children with autism to experience a folic acid deficiency. One cause of weak methylation processes that keep folic acid from being transformed into Tetrahydrofolate is defective biochemistry.
Dietary issues are another common cause, particularly when certain foods high in folic acid (i.e., spinach, broccoli, beets, lettuce, green peas, whole rice, lentils, etc.) are absent from the child’s meals.
Inflammatory bowel disease and celiac disease can also be to blame. These conditions are known to disrupt the intestinal wall’s overall function and decrease the absorption of folic acid.
Additionally, folate deficiency may be the result of weak absorption of specific vitamins, including niacin, riboflavin, and thiamine. Cobalamin (vitamin B12) deficiency is another possible cause known to contribute to both anemia and folic acid deficiency.
Problems related to glutathione—an antioxidant capable of stopping damage to vital cell structure—can cause similar challenges. So, too can mental strain and stress, which decrease the body’s B vitamins. And for children experiencing
diarrhea frequently, vitamin secretion—including the secretion of folic acid—may occur.
Detecting a Folic Acid Deficiency
To detect a folic acid deficiency, a blood sample must be taken. From there, the folate deficiency can be identified as large red blood cells (a sign of globular anemia).
High uracil levels in urine tests for organic acids can also indicate folic acid metabolism deficiency.
This is because increased uracil levels are a sign of deficiency involving an enzyme called Dihydropyrimidine dehydrogenase, which can cause neurological problems. In this way, testing is key to determining whether a folic acid deficiency may be at play.
How Can Folic Acid Deficiency Be Treated in Children with Autism?
The administration of folic acid must be performed only in accordance with the patient’s test results.
Doses must be controlled carefully and based on recommendations from a reputable source. This is because overdosing on folic acid can lead to gas, bloating, kidney stones, and nausea.
Ultimately, administering folic acid in a controlled manner can treat deficiencies and encourage the proper function of the nervous system. This can help to regulate digestive performance, enhance the immune system, and cultivate healthier sleep cycles.
The information in this article is exclusively for general knowledge purposes. It should not be used for personal treatment or as a substitute for medical advice. There is no representation or warranty, explicit or implied, involving the accuracy, validity, or completeness of the content in this piece. Nutritional supplementation should only occur under the supervision of a licensed professional (and in accordance with laboratory test results).
Do you have questions about the content of this article? Please contact us for more information.
Dreams Can Come True
Dreams Can Come True
Within five therapy months, Matteo’s remarkable progress in communication, verbalization, and understanding abilities enabled him to overcome the criteria of autism.
See How C.A.T.’s Targeted Nutritional Supplements Therapy Changed Three-Years-Old Lior’s Life.
See How C.A.T.’s Targeted Nutritional Supplements Therapy Changed Three-Years-Old Lior’s Life.
In May 2020, we embarked on a fascinating documentary journey. For five months, we filmed Lior and his parents. The film documents his targeted therapy and teaches how it is possible to dramatically reduce autism symptoms by analyzing advanced laboratory tests and applying an in-depth understanding of how to repair impaired metabolic processes that influence behaviors.
***C.A.T is accessible worldwide as it relies on laboratory test results that can be obtained at the C.A.T Center in Israel or by collecting samples independently and sending them via FedEx express delivery directly to US and UK laboratories. In this case, we will provide the necessary laboratory test kits with detailed collection and shipping instructions.

